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Impaired insulin secretion is closely associated with type 2 diabetes, but the process is not yet fully understood. A new study by researchers at Lund University shows that the Piezo1 ion channel regulates insulin secretion, which means it may be an important target for new diabetes treatments. Type 2 diabetes often occurs because the pancreatic beta cells are unable to produce enough effective in

https://www.medicine.lu.se/article/study-shows-piezo1-ion-channel-plays-important-role-insulin-secretion - 2025-10-03

B cells and the antibodies they produce play an important role in our immune system, protecting us from the microscopic enemies that make us ill. Uncovering how they form and are ‘programmed’ during development is key to better understanding the immune response to infections and vaccinations. A new study by researchers from Lund University in Sweden provides new insights into the origin and develo

https://www.medicine.lu.se/article/how-b-cells-are-programmed-early-life-can-impact-long-term-immune-health - 2025-10-03

Göran Jönsson, Professor of Molecular Oncology, has been granted SEK 31 million from the Knut and Alice Wallenberg Foundation to improve the effect of immunotherapy in the treatment of cancer patients. About 30 percent of melanoma patients with metastatic disease benefit from immunotherapy. At the same time, this means that 70 percent of all melanoma patients still lack effective treatment options

https://www.medicine.lu.se/article/sek-31-million-more-effective-immunotherapy-cancer-treatment - 2025-10-03

Locked fingers, known as trigger finger, are more common among people with diabetes than in the general population. A study led by Lund University in Sweden shows that the risk of being affected increases in the case of high blood sugar. The study has been published in Diabetes Care. Trigger finger means that one or more fingers, often the ring finger or thumb, ends up in a bent position that is d

https://www.medicine.lu.se/article/hands-people-diabetes-more-often-affected-trigger-finger - 2025-10-03

Professor Oksana Tymoshchuk came to Lund with her children as soon as the opportunity arose. She also wanted to help students from her home university escape the ongoing turmoil in Ukraine. Now four medical students have arrived to study here for six months with a full Erasmus scholarship. “It’s a fantastic opportunity, with such practical studies. The other week I got to stitch up a Cesarean!” “I

https://www.medicine.lu.se/article/ukrainian-medical-students-arrive-lund-after-lightning-fast-application-process - 2025-10-03

A large study led by Lund University in Sweden has shown that people with Alzheimer's disease can now be identified before they experience any symptoms. It is now also possible to predict who will deteriorate within the next few years. The study is published in Nature Medicine, and is very timely in light of the recent development of new drugs for Alzheimer's disease. It has long been known that t

https://www.medicine.lu.se/article/alzheimers-disease-can-be-diagnosed-symptoms-emerge - 2025-10-03

Researchers at Lund University in Sweden have identified one of the reasons why the childhood cancer neuroblastoma becomes resistant to chemotherapy. The findings are significant for how future treatments should be designed. The results have been published in Science Advances. Neuroblastoma is an aggressive cancer of the sympathetic nervous system, especially of the adrenal gland. Despite intense

https://www.medicine.lu.se/article/altered-cell-behaviour-behind-resistance-neuroblastoma - 2025-10-03

Sometimes healthcare professionals treat patients with opioids such as morphine to relieve symptoms, but there has been a lack of evidence as to whether this helps with severe chronic breathlessness. A randomised Phase 3 study conducted by Swedish and Australian researchers now finds that morphine does not reduce worst breathlessness. The study is published in JAMA. Long term shortness of breath i

https://www.medicine.lu.se/article/new-study-morphine-treatment-people-copd-and-severe-long-term-breathlessness - 2025-10-03

Two world-leading American researchers known respectively for their research within medical humanities, and the sensory nervous system and perception of pain and temperature have been named honorary doctors at the Faculty of Medicine. The honorary doctorates will be conferred on 26 May 2023. Ever since David Julius’ discovery of the temperature and pain receptor TRPV1, he has contributed crucial d

https://www.medicine.lu.se/article/honorary-doctors-named-faculty-medicine - 2025-10-03

Last year's Nobel celebration was a digital version, but this year David Julius, who won the Nobel prize in Medicine or Physiology in 2021, will travel to Stockholm for the festivities. In this interview he talks about what such a prize leads to, about the joy of curiosity-driven research that, although lacking guardrails, is full of creativity and opportunities – and about the similarity between

https://www.medicine.lu.se/article/his-interest-natural-products-led-nobel-prize - 2025-10-03

Southern Scandinavia and Northern Germany form a leading life science region with unique research infrastructures that can help transform research into innovation. There is especially a large unused potential for industrial and clinical researchers to use these unique facilities. The HALRIC consortium led by Lund University has now received EU funding to build collaborations between companies, hos

https://www.medicine.lu.se/article/11-million-euros-life-science-research-and-innovation-infrastructure-synergies-northern-europe - 2025-10-03

Researchers at Lund University in Sweden have discovered an antibody with the potential to protect against Strep A infection, as well as a rare form of antibody binding, that leads to an effective immune response against bacteria. The discovery could explain why so many Group A strep vaccines have failed. The results are published in EMBO Molecular medicine. Group A streptococci have several ways

https://www.medicine.lu.se/article/antibody-discovery-paves-way-new-therapies-against-group-streptococcal-infections - 2025-10-03

Stem cells programmed to produce insulin in people with type 1 diabetes or to repair the heart muscle after a heart attack. Gene and cell therapies that improve cancer treatments. These new and innovative therapies have the potential to cure, alleviate and treat diseases where traditional medicines are currently insufficient. The monk Gregor Mendel set more in motion than he could have imagined wh

https://www.medicine.lu.se/article/advanced-treatments-future-are-soon-here - 2025-10-03

For risk groups, a common cold can be life-threatening. Researchers in Lund have contributed to the development of a new biological medicinal product to treat severe asthma that is worsened by colds. The hope is that the drug will be approved in Sweden next year. Young children, the elderly and patients suffering from chronic lung disease such as asthma and COPD run an increased risk of being affl

https://www.medicine.lu.se/article/when-common-cold-becomes-life-threatening - 2025-10-03

The Lung Bioengineering and Regeneration research group is made up of about 15 researchers focusing on chronic lung disease. The group’s work includes the development of different methods to study disease models for conditions such as COPD and pulmonary fibrosis. One of the researchers, John Stegmayr, has been awarded SEK 700,000 from the Carl Tesdorpf Foundation to expand research into idiopathic

https://www.medicine.lu.se/article/focusing-chronic-lung-disease - 2025-10-03

How much water do we need to drink to stay healthy? How do different diets affect our metabolism? Studies of various hormones in the body are providing diabetes researchers with new answers to these questions. The goal is to develop individualized treatments and dietary recommendations that could lower the risk of developing obesity and diseases such as type 2 diabetes. The endocrine system and th

https://www.medicine.lu.se/article/learning-more-about-endocrine-system-could-lead-fewer-cases-type-2-diabetes-and-obesity - 2025-10-03

Two innovation-driven research projects at Lund University have been awarded a Proof of Concept Grant by the European Research Council, ERC. They relate to biomarkers for predicting who benefits from metformin in the treatment of type 2 diabetes and new technology to enable powerful and focused therapies for the treatment of solid tumours. Charlotte Ling has been awarded an ERC Proof of Concept Gr

https://www.medicine.lu.se/article/erc-grants-research-diabetes-and-immunotherapy - 2025-10-03

For up to 40 years, nearly 800,000 people from Sweden, Norway and Austria have been tracked based on how their BMI and metabolic health – that is, their blood pressure, blood glucose levels and blood fats - affect the risk of suffering from obesity-related cancers. The study shows that those who are metabolically unhealthy are at a higher risk of certain forms of cancer, regardless of their body w

https://www.medicine.lu.se/article/metabolic-health-plays-role-obesity-related-cancers - 2025-10-03

Certain complications during pregnancy bring an increased risk of heart disease later on. However, there is still much to learn about how arteriosclerosis develops between pregnancy and heart disease later in life. A large new study led by researchers from Lund University in Sweden shows that narrowing and calcification of the blood vessels of the heart are more common in women previously affected

https://www.medicine.lu.se/article/complications-pregnancy-linked-increased-risk-heart-disease - 2025-10-03

Researchers have identified 395 genes that are differently expressed in people with type 2 diabetes. One of the genes proved to be very strongly associated with impaired insulin secretion. Now, researchers want to investigate if it is possible to use the genetic CRISPR/Cas9 scissors to correct the gene’s activity. The research team’s scientific paper was published in the Journal of Clinical Invest

https://www.medicine.lu.se/article/pax5-gene-strongly-associated-impaired-insulin-secretion-type-2-diabetes - 2025-10-03